Category: Chronic Pain

As the prevalence of diabetes mellitus continues to rise throughout the world, so do the complications associated with this disease. Neuropathy is a common and serious complication associated with diabetes. The peripheral sensory type of diabetic neuropathy (DPN) is implicated as a causal factor in the development of foot ulcerations, infections, and amputations. The loss of sensation in DPN has been shown to be a key component in the formation of foot ulcerations.

Neuropathic pain is the result of damage (due to injury or disease) to the nervous system (including nerves), spinal cord and other central nervous system regions. Neuropathy patients suffer from spontaneous pain, allodynia (pain response to normally innocuous stimuli) and hyperalgesia (aggravated pain evoked by noxious stimuli) that interferes with their quality of life. Several experimental models have been developed to better understand neuropathy. The chronic constriction injury (CCI) model, developed by Bennett and Xie, is a widely used model of mononeuropathy that replicates in rats most of the symptoms occurring in patients.

The application of
laser therapy, either alone or combined with other treatments,
both pharmacological and instrumental, has its rationale in the
therapeutic effects that are attributed to laser radiation: analgesic,
anti-inflammatory, anti-oedema and ability to promote wound
healing and tissue repair.

The aim of this case series is to report on the effect of MiS, a new laser therapy device which uses two synchronized emissions with 905 nm and 808 nm wavelengths, pulsed and continuous, respectively, with high peak power, in the management of neuropathic pain.