ABSTRACT The aim of this case series is to report on the effect of MiS, a new laser therapy device which uses two synchronized emissions with 905 nm and 808 nm wavelengths, pulsed and continuous, respectively, with high peak power, in the management of neuropathic pain. A total of 43 patients (mean age: 53 years, from 23 to 85 years) presenting neuropathic pain associated to different anatomical areas, such as cervical zone, spine, foot/ankle, hand/ wrist, shoulder, elbow, hip and knee were treated with laser therapy by MiS. Pain (VAS score) and functionality (therapist evaluation) were evaluated at the end of treatment. The severity of pain decreased over time and was lower at the end of treatment. MiS laser therapy demonstrated to be safe and effective in patients affected by neuropathic pain and represents a valuable tool for the management of these patients.