Science & Studies

Laser energy produces changes in oxidation/reduction status of the mitochondria which lead to dramatic increases in ATP synthesis. Activation of the sodium/potassium pump alters the following ways.

  • Stimulates cell growth
  • Increases cell metabolism
  • Improves cell regeneration
  • Produces an anti-inflammatory response
  • Produces edema reduction
  • Reduces fibrous tissue formation
  • Stimulates nerve function
  • Reduces the production of Substance P
  • Stimulates long-term production of nitric oxide

The Effect of Low-Level Laser on Postoperative Pain After Tibial Fracture Surgery: A Double-Blind Controlled Randomized Clinical Trial


One of the undesirable complications of surgery is postoperative pain that may result in serious morbidities such as agitation, hypertension, mood changing, tachycardia and delay in wound healing, which can be more dangerous in patients with the underlying diabetes mellitus, hypertension, or coronary heart diseases as it may lead to fatal complications such as myocardial infarction. There is a high variability among patients in tolerance to pain and analgesic requirement. The studies show that about 80% of patients experience a mild to severe pain after surgery.

The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial


Since Endre Mester began his pioneering investigations, numerous clinical and basic research studies have demonstrated the physiological effects and medical applicability of low-level laser therapy (LLLT). Its application was initiated based on previous work that demonstrated properties of low-level laser that exert a positive influence on fibroblast and osteoblast proliferation, collagen synthesis, and bone regeneration. In vivo examinations have also shown that LLLT significantly stimulates the activity of alcalic phosphatase and calcium accumulation.

The affect of MLS therapy on nerve conduction parameters in developing diabetic sensory peripheral neuropathy.


As the prevalence of diabetes mellitus continues to rise throughout the world, so do the complications associated with this disease. Neuropathy is a common and serious complication associated with diabetes. The peripheral sensory type of diabetic neuropathy (DPN) is implicated as a causal factor in the development of foot ulcerations, infections, and amputations. The loss of sensation in DPN has been shown to be a key component in the formation of foot ulcerations.

Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty—a randomized, triple-blind, placebo-controlled clinical trial


Osteoarthritis (OA) is a degenerative joint disease characterized by the wear of articular cartilage, marginal osteophyte formation, ligament, synovial and meniscal changes, and damages of the subchondral bone. During the early stages of the disease, the degenerative process is slow but progresses over time.

Efficacy of class IV diode laser on pain and dysfunction in patients with knee osteoarthritis- a randomized placebo-control trial


The most commonly involved joint is the knee with impaired life quality and associated morbidity. Knee OA commonly affects the elderly, and especially women. One-third of the people aged 65 years and older have knee OA, which is evident by radiography. The incidence of the OA tends to increase with aging, with increasing pain and disability of the lower limb, which can seriously affect one's life activities.

Effect of MLS® Laser Therapy for the treatment of experimentally induced acute tendinopathy in sheep – a preliminary study.


Overuse tendinitis and other tendon injuries are common among athletes and represent a frequent cause of lameness in sport horses. In the human medical field, Low Level Laser Therapy (LLLT) has been used to treat acute and chronic musculoskeletal pain and foster wound healing. However, few studies have evaluated its effectiveness in treating patients with acute tendonitis and other tendinopathies.

Effect of NIR laser therapy by MLS- MiS source against neuropathic pain in rats: in vivo and ex vivo analysis


Neuropathic pain is the result of damage (due to injury or disease) to the nervous system (including nerves), spinal cord and other central nervous system regions. Neuropathy patients suffer from spontaneous pain, allodynia (pain response to normally innocuous stimuli) and hyperalgesia (aggravated pain evoked by noxious stimuli) that interferes with their quality of life. Several experimental models have been developed to better understand neuropathy. The chronic constriction injury (CCI) model, developed by Bennett and Xie, is a widely used model of mononeuropathy that replicates in rats most of the symptoms occurring in patients.

Effect of IR Laser on Myoblasts: Prospects of Application for Counteracting Microgravity-Induced Muscle Atrophy


Aging and disuse, as occurs in bed rest and spaceflights, induce in skeletal muscle a reductive remodelling and may lead to atrophy. The mechanisms underlying muscle atrophy caused by disuse and muscle aging have some similarities: in both the lack of mechanical stimuli plays a relevant role

A systematic review with procedural assessments and meta-analysis of Low Level Laser Therapy in lateral elbow tendinopathy (tennis elbow)


LLLT administered with optimal doses of 904 nm and possibly 632 nm wavelengths directly to the lateral elbow tendon insertions, seem to offer short-term pain relief and less disability in LET, both alone and in conjunction with an exercise regimen.

Magnetic Resonance Imaging and Clinical Outcomes of Laser Therapy, Ultrasound Therapy, and Extracorporeal Shock Wave Therapy for Treatment of Plantar Fasciitis: A Randomized Controlled Trial


We determined and compared the effectiveness of low-level laser therapy (LLLT), therapeutic ultrasound (US) therapy, and extracorporeal shock wave therapy (ESWT) using magnetic resonance imaging (MRI). We performed a randomized, prospective, comparative clinical study.

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